Seelye is a surname. Notable people with the surname include:
Frederick Thomas Seelye (1879–1962), New Zealand chemist and academic
Gilbert T. Seelye (1877–1928), New York politician
Julius Hawley Seelye (1824–1895), American missionary, writer and politician
Kate Seelye, American journalist
Laurenus Clark Seelye (1837–1924), American college president
Talcott Williams Seelye (1922–2006), American diplomat and writer