Sebastiano is both a masculine Italian given name and a surname. Notable people with the name include:
Sebastiano Antonio Tanara (1650–1724), Italian cardinalSebastiano Baggio (1913–1993), Italian clergymanSebastiano Bianchi (16th century), Italian engraverSebastiano Bombelli (1635–1724), Italian painterSebastiano Brunetti (died 1649), Italian painterSebastiano Carezo (21st century), Spanish dancerSebastiano Conca (c. 1680 – 1764), Italian painterSebastiano del Piombo (c. 1485 – 1547), Italian Renaissance-Mannerist painterSebastiano Dolci (1699–1777), Croatian writerSebastiano Filippi (c. 1536 – 1602), Italian late Renaissance-Mannerist painterSebastiano Galeotti (1656–1746), Italian painterSebastiano Ghezzi (1580–1645), Italian painter and architectSebastiano Guala (17th century), Italian church architectSebastiano Martinelli (1848–1918), Cardinal of the Roman Catholic ChurchSebastiano Mazzoni (c. 1611 – 1678), Italian painterSebastiano Mocenigo (1662–1732), Doge of VeniceSebastiano Nela (born 1961), Italian ex-footballerSebastiano Nicola Buonaparte (c. 1683 – 1720), Elder of the Council of the City of AjaccioSebastiano Ricci (1659–1834), Italian painterSebastiano Rossi (born 1964), Italian footballerSebastiano Santi (1788–1866), Italian painterSebastiano Serafini (born 1990), Italian actor, model, and musicianSebastiano Serlio (c. 1475 – 1554), Italian Mannerist architectSebastiano Siviglia (born 1973), Italian football defenderSebastiano Taricco (1645–1710), Italian painterSebastiano Timpanaro (1923–2000), Italian classical philologist, essayist, and literary criticSebastiano Venier (c. 1496 – 1578), Doge of VeniceSebastiano Visconti Prasca (1883–1961), Italian military officerSebastiano Ximenes (16th century), Italian bankerSebastiano Ziani (12th century), Doge of VeniceRichiardi Sebastiano (1834–1904), Italian anatomist and zoologist