Schiaffino is an Italian surname. Notable people with the surname include:
Bernardo Schiaffino (1678–1725), Italian Baroque sculptorDavid Schiaffino (1913–2005), Argentine sport shooterEduardo Schiaffino (1858–1935), Argentine painter, critic, intellectual and historianFrancesco Maria Schiaffino (1688–1763), Italian Baroque sculptorJuan Alberto Schiaffino (1925–2002), Italian-Uruguayan footballerRosanna Schiaffino (1939–2009), Italian actress