Sca-1 stands for "Stem cells antigen-1". It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. It is the common biological marker used to identify hematopoitic stem cell (HSC) along with other markers.
Application of Sca-1
- Sca-1 has a regenerative role in cardiac repair: Endogenous Sca-1+CD31− cells upon myocardial infarction as well as Sca-1 protein.
- Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.
References
Sca-1 Wikipedia(Text) CC BY-SA