Saxe is a surname. Notable people with the surname include:
Adrian Saxe (born 1943), American ceramistDavid B. Saxe (born 1942), American judgeDavid Saxe (born 1969), American theatrical producerEdward Saxe (1916–2002), War intelligence, CBS executive, MOMA director, New York Harvard Club PresidentJohn Godfrey Saxe (1816–1887), American poetJohn Godfrey Saxe II (1877–1953), American politicianJohn Theodore Saxe (1843–1881), of Albany AcademyMartin Saxe (1874–1967), New York politicianMaurice de Saxe (1696–1750), military figure, Marshal General of FranceMelinda Saxe (born 1965), American magicianRebecca Saxe, MIT neuroscientistSusan Edith Saxe (born 1949), one of the FBI's Ten Most Wanted Fugitives in the first half of the 1970s