Sauvagine

Sauvagine is a protein that functions as a neuropeptide. It is 40 amino acids in length, and has sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagei, but has been hypothesised to be produced endogenously by mammals, as it produces similar physiological effects to endogenous neuropeptides such as Corticotropin-releasing hormone.

Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urotensin I, urocortin, urocortin II and urocortin III.