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Santissima Trinità is a Renaissance-style, Roman Catholic church in via Elisa in central Lucca, region of Tuscany, Italy.
The church was once affiliated with Barnabite order of nuns, with an adjacent hospital for the convalescent, later by a Salesian order
The church was completed in 1595 and the design, with a facade with rusticated pilasters and roof-top obelisks, is attributed to Bartolommeo Ammannati or his followers. The church has an elaborate main altar with polychrome marble, an painted architecture. The main altarpiece of the Trinity with Saints John the Baptist, Paolino, Sebastian, Antony, and Catherine by Pietro Paolini. A side altar has a sculpted marble Lactating Madonna (also called Madonna della Tosse or della Latte) by Matteo Civitali. The ceiling has a frescoed oval by Trinity (1595) by Pietro Sorri. Other works lateral to the main altar were completed by Domenico Brugieri circa 1721.
Under the main altar is a glass box with a gilded statue holding relics.