Salzer, otherwise Saltzer and Sälzer, is a German surname meaning "salter". Notable people with this surname include the following:
Bernhard Sälzer (1940–1993), German MEP
Bruno Sälzer (born 1957), German CEO of Escada, international luxury fashion group
Else Rambausek-Salzer (1907–1994), Austrian actress and singer
Felix Salzer (1904–1986), Austrian-American music theorist and musicologist
Jerry Saltzer (born 1939), American computer scientist
Otto Salzer (1874–1944), German racing car driver
Robert Samuel Salzer (1919–1988), Vice Admiral of the United States Navy
Sage Salzer (born 1973), plus-size model and advocate