Sakaguchi (坂口) is a Japanese surname. Notable people with the surname include:
Alicja Sakaguchi (born 1954), a Polish linguist
Ango Sakaguchi (1906–1955), a Japanese novelist and essayist
Chikara Sakaguchi (born 1934), a Japanese politician
Daisuke Sakaguchi (born 1973), a Japanese voice actor
Hironobu Sakaguchi (born 1962), a Japanese game designer, game director and game producer
Hiroyuki Sakaguchi (born 1965), a Japanese baseball player
Kenji Sakaguchi (actor) (born 1975), a Japanese actor
Kenji Sakaguchi (footballer) (born 1975), a former Japanese football player
Kinichiro Sakaguchi ( 1897- 1994), a Japanese agricultural chemist and microbiologist
Kōichi Sakaguchi, a Japanese voice actor
Seiji Sakaguchi (born 1942), a retired Japanese professional wrestler
Shūhei Sakaguchi (born 1977), a Japanese voice actor
Tak Sakaguchi (born 1975), a Japanese actor, director, fight choreographer and stuntman
Yoshisada Sakaguchi (born 1939), a Japanese actor and voice actor
Yukio Sakaguchi (born 1973), a Japanese mixed martial artist and professional wrestler
Fictional characters:
Alice Sakaguchi, the main character from Please Save My Earth
