Sailer is a surname. Notable people with the surname include:
Chris Sailer (born 1977), American football player and trainerFriederike Sailer (1920–1994), German sopranoJohann Michael Sailer (1751–1832), German Jesuit professor of theology and Bishop of RatisbonSebastian Sailer (1714–1777), German Premonstratensian Baroque preacher and writerSteve Sailer (born 1958), American journalist and film criticToni Sailer (1935–2009), Austrian skierVerena Sailer (born 1985), German athlete