Safonov (Russian: Сафонов) and Safonova (Russian: Сафонова; feminine) is a Russian surname. Notable people with the surname include:
Andrey Safonov (b. 1964), politician from TransnistriaBoris Safonov (1915–1942), World War II flying aceIgor Safonov, Soviet sprint canoerMikhail Safonov (pilot) (1893–1924), World War I flying aceOleg Safonov (b. 1960), Russian politicianOleksandr Safonov (b. 1991), Ukrainian football playerVasily Ilyich Safonov (1852–1918), Russian pianist, teacher, conductor and composerYevgeni Safonov (disambiguation), several peopleDarya Safonova (b. 1981), Russian sprinterElena Safonova (b. 1956), Soviet and Russian film actressAnna Safonova (1883–1975), maiden name of Anna Timiryova, daughter of Vasily Ilyich Safonov