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Saco is an unincorporated community in Twelvemile Township in southern Madison County, Missouri, United States. It is located about sixteen miles southwest of Fredericktown on Missouri Supplemental Route C.
Map of Saco, Twelvemile Township, MO 63645, USA
A post office called Saco was established in 1892, and remained in operation until 1979. It is unclear why the name Saco was applied to this community.
References
Saco, Missouri Wikipedia(Text) CC BY-SA