Sabatini is an Italian surname. Notable people with the surname include:
Bettina Sabatini (born 1966), Italian marathon runner
Gabriela Sabatini (born 1970), Argentine female tennis player
Gaetano Sabatini (1703–1734), Italian draftsman and painter
Lorenzo Sabatini (1530–1576), Italian painter of the Mannerist period from Bologna
Rafael Sabatini (1875–1950), Italian/British author of novels of romance and adventure, such as Scaramouche, Sea Hawk and Captain Blood
Sandra Sabatini (born 1959), Canadian writer
Francesco Sabatini (1722–1797), Italian architect who worked in Spain
Fabio Sabatini (born 1985), Italian road bicycle racer
Walter Sabatini (born 1955), Italian former association football player turned director of football, currently working for Italian club AS Roma
David M. Sabatini (born 1968), American cell biologist and biochemist and a professor at the Whitehead Institute and the Massachusetts Institute of Technology