Species Human Entrez 23512 | Human Mouse Ensembl ENSG00000178691 | |
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Aliases SUZ12, CHET9, JJAZ1, SUZ12 polycomb repressive complex 2 subunit External IDs MGI: 1261758 HomoloGene: 32256 GeneCards: SUZ12 | ||
Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.
Function
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.
SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.
References
SUZ12 Wikipedia(Text) CC BY-SA