Trisha Shetty (Editor)

SUMF2

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Covid-19
Species  Human
Entrez  25870
Human  Mouse
Ensembl  ENSG00000129103
SUMF2
Aliases  SUMF2, pFGE, sulfatase modifying factor 2
External IDs  MGI: 1915152 HomoloGene: 41037 GeneCards: SUMF2

Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene.

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

SUMF2 Wikipedia


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