Aliases SRD5A2, entrez:6716 Human Mouse Ensembl ENSG00000277893 | Species Human Entrez 6716 | |
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External IDs OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2 |
3-oxo-5-alpha-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.
Steroid 5-alpha reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
References
SRD5A2 Wikipedia(Text) CC BY-SA