Puneet Varma (Editor)

SPPL2B

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Species
  
Entrez
  
56928

Human
  
Ensembl
  
ENSG00000005206

SPPL2B

Aliases
  
SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B

External IDs
  
MGI: 1920468 HomoloGene: 10605 GeneCards: SPPL2B

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. Multiple transcript variants encoding different isoforms have been found for this gene.

References

SPPL2B Wikipedia


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