Kalpana Kalpana (Editor)

SPPL2A

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Species
  
Human

Entrez
  
84888

Human
  
Mouse

Ensembl
  
ENSG00000138600

SPPL2A

Aliases
  
SPPL2A, IMP3, PSL2, signal peptide peptidase like 2A

External IDs
  
MGI: 1913802 HomoloGene: 36411 GeneCards: SPPL2A

Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.

Function

This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. A pseudogene of this gene also lies on chromosome 15.

References

SPPL2A Wikipedia