Species Human Entrez 9306 | Human Mouse Ensembl ENSG00000170677 | |
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Aliases SOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6 External IDs MGI: 1924885 HomoloGene: 3120 GeneCards: SOCS6 | ||
Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
References
SOCS6 Wikipedia(Text) CC BY-SA