Species Human Entrez 6642 | Human Mouse Ensembl ENSG00000028528 | |
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Aliases SNX1, HsT17379, VPS5, sorting nexin 1 External IDs OMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1 | ||
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.
References
SNX1 Wikipedia(Text) CC BY-SA