Species Human Entrez 6522 | Human Mouse Ensembl ENSG00000164889 | |
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Aliases SLC4A2, AE2, BND3L, EPB3L1, HKB3, NBND3, solute carrier family 4 member 2 External IDs MGI: 109351 HomoloGene: 128699 GeneCards: SLC4A2 | ||
Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3− transport in the gastrointestinal tract. AE2 is required for spermiogenesis in mice. AE2 is required for normal osteoclast function. The activity of AE2 is sensitive to pH.
AE3 has been suggested as a target for prevention of diabetic vasculopathy.
References
SLC4A2 Wikipedia(Text) CC BY-SA