Species Human Entrez 9376 | Human Mouse Ensembl ENSG00000149452 | |
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Aliases SLC22A8, OAT3, solute carrier family 22 member 8 External IDs MGI: 1336187 HomoloGene: 20901 GeneCards: SLC22A8 | ||
Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.
Function
OAT3 is involved in the transport and excretion of organic ions some of which are drugs (e.g., penicillin G (benzylpenicillin), methotrexate (MTX), indomethacin (an NSAID), and ciprofloxacin (a fluoroquinolone antibiotic)) and some of which are pure toxicants. SLC22A8 (OAT3) is indirectly dependent on the inward sodium gradient, which is a driving force for reentry of dicarboxylates into the cytosol. Dicarboxylates, such as alpha-ketoglutarate generated within the cell, or recycled from the extracellular space, are used as exchange substrates to fuel the influx of organic anions against their concentration gradient. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of renal proximal tubule cells.