Species Human Entrez 6556 | Human Mouse Ensembl ENSG00000018280 | |
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Aliases SLC11A1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1 External IDs MGI: 1345275 HomoloGene: 73884 GeneCards: SLC11A1 | ||
Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.
Function
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.