Species Human Entrez 6555 | Human Mouse Ensembl ENSG00000125255 | |
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Aliases SLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2 External IDs MGI: 1201406 HomoloGene: 390 GeneCards: SLC10A2 | ||
The SLC10A2 (solute carrier family 10 member 2) gene in humans encodes the bile acid:sodium symporter known as the apical sodium–bile acid transporter (ASBT) or as the ileal bile acid transporter (IBAT).
ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.
As a drug target
Several medications to inhibit IBAT are under development. They include elobixibat, under development for the treatment of constipation and irritable bowel syndrome, and volixibat, under development for the treatment of nonalcoholic steatohepatitis.
References
SLC10A2 Wikipedia(Text) CC BY-SA