Entrez 51763 | Ensembl ENSG00000132376 | |
 | ||
Aliases INPP5K, PPS, SKIP, inositol polyphosphate-5-phosphatase K External IDs MGI: 1194899 HomoloGene: 75059 GeneCards: INPP5K | ||
SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.
Function
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.
References
SKIP Wikipedia(Text) CC BY-SA