Species Human Entrez 5276 | Human Mouse Ensembl ENSG00000114204 | |
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Aliases SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2 External IDs MGI: 1915181 HomoloGene: 21248 GeneCards: SERPINI2 | ||
Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.
Function
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.