Suvarna Garge (Editor)

SCIN

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Aliases
  
SCIN

Human
  
Ensembl
  
ENSG00000006747

Species
  
Entrez
  
85477

SCIN

External IDs
  
MGI: 1306794 HomoloGene: 36296 GeneCards: SCIN

Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, Calcium channels open allowing calcim ions to enter de secretory cell. Increase in intracellualr calcium activates scinderin with the consecuent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

References

SCIN Wikipedia


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