EC number 2.7.1.100 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 68247-56-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a S-methyl-5-thioribose kinase (EC 2.7.1.100) is an enzyme that catalyzes the chemical reaction
ATP + S-methyl-5-thio-D-riboseThus, the two substrates of this enzyme are ATP and S-methyl-5-thio-D-ribose, whereas its two products are ADP and S-methyl-5-thio-alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase. Other names in common use include 5-methylthioribose kinase (phosphorylating), methylthioribose kinase, 5-methylthioribose kinase, and ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase. This enzyme participates in methionine metabolism.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OLC, 2PU8, 2PUI, 2PUL, 2PUN, and 2PUP.