EC number 2.4.2.28 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 61970-06-7 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) is an enzyme that catalyzes the chemical reaction
S-methyl-5'-thioadenosine + phosphateThus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and phosphate, whereas its two products are adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. Other names in common use include 5'-methylthioadenosine nucleosidase, 5'-deoxy-5'-methylthioadenosine phosphorylase, MTA phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine phosphorylase, methylthioadenosine nucleoside phosphorylase, 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase, and S-methyl-5-thioadenosine phosphorylase. This enzyme participates in methionine metabolism.
Structural studies
As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1CB0, 1CG6, 1JDS, 1JDT, 1JDU, 1JDV, 1JDZ, 1JE0, 1JE1, 1JP7, 1JPV, 1K27, 1ODI, 1ODJ, 1ODK, 1SD1, 1SD2, 1V4N, 1WTA, and 2A8Y.