Rupe is a masculine given name, often a diminutive form (hypocorism) of Rupert. People named Rupe include:
Rupert Rupe Andrews (1926-2008), American player in the Canadian Football LeagueRupe Benstead (1889–1961), Australian rules footballerRupe Bethune (1917–1984), Australian rules footballerRupe Brownlees (1888–1960), Australian rules footballerRupe Dodd (1907–1998), Australian rules footballerRupe Hannah (1900-1983), Australian rules footballerRupert Rupe Hiskins (1893–1976), Australian rules footballerRupe Hutton (1906–1987), Australian rules footballerRupe Lowell (1893–1980), Australian rules footballerRupe McDonald (1910–1969), Australian rules footballerRupe Perrett (1909-1966), Australian rules footballerRupert Smith (American football) (1897-1959), American college football player