Runkle is a surname. Notable people with the surname include:
Benjamin Piatt Runkle, (1836–1916), founder of Sigma Chi fraternity, colonel in the Union Army during the American Civil War
Bertha Runkle (1879–1958), American novelist and playwright
John Daniel Runkle (1822–1902), US educator and mathematician
Nathan Runkle (b. 1984), American animal rights advocate
Theadora Van Runkle (1929–2011), American costume designer
