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The rule of six is feature of some paramyxovirus genomes. These are RNA viruses which have genes made from RNA and not DNA, and their whole genome – that is the number of nucleotides – is always a multiple of six. This is because during their replication, these viruses are dependent on nucleoprotein molecules that each bind to six nucleotides.
References
Rule of six (viruses) Wikipedia(Text) CC BY-SA