Rubini is a surname of Italian origin. Notable people with the surname include:
Cesare Rubini, Italian basketball player
Gabriele Rubini, Italian television presenter
Giambattista Rubini, Italian Catholic cardinal
Giovanni Battista Rubini, Italian tenor
Giulia Rubini, Italian actress
Michel Rubini, American musician and composer
Olinto Sampaio Rubini, Brazilian footballer
Sergio Rubini, Italian actor and film director