Gene HTR2A Ensembl Human SNPView HapMap 6311 | Chromosome 13 dbSNP 6311 | |
Name(s) -1438G/A, -1438A/G, A-1438G, G-1428A | ||
In genetics rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory or with a psychological task measuring impulsive behavior. The SNP has also been investigated in rheumatology studies.
Some research studies may refer to this gene variation as a C/T SNP, while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.
As of 2008, meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.
rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene.