Roxanne is a feminine given name. Notable people with the name include:
Roxanne Avent (born 1976), American film producer and movie studio executive
Roxanne Barcelo (born 1985), Filipino-American actress, model and singer
Roxanne Barker (born 1991), South African football goalkeeper
Roxanne Beck, American singer and voice actress
Roxanne Beckford (born 1969), American actress
Roxanne Blaze (born 1974), American pornographic actress
Roxanne Bovenberg (born 1989), Dutch handball player
Roxanne Conlin (born 1944), United States Attorney for the Southern District of Iowa
Roxanne Constantin, Canadian musician
Roxanne Donnery American politician from New York
Roxanne Dunbar-Ortiz (born 1939), American historian, writer and feminist
Roxanne Emery (born 1984), English singer-songwriter, multi-instrumentalist and producer
Roxanne Fontana (born 1959), Italian-American author and musician
Roxanne Guinoo (born 1986), Filipino actress
Roxanne Hart (born 1952), American actress
Roxanne James (born 1966), Canadian politician
Roxanne Jones (1928–1996), American politician from Pennsylvania
Roxanne Kernohan (1960–1993), Canadian actress
Roxanne Lowit, New York-based fashion and celebrity photographer
Roxanne McKee (born 1980), English actress and model
Roxanne Modafferi (born 1982), American mixed martial artist
Roxanne Didier Nicholas (born 1992), St. Lucian dancer and beauty pageant titleholder
Roxanne Pallett (born 1982), English actress and singer
Roxanne Persaud, American politician from New York
Roxanne Porter (born 1990), Canadian rhythmic gymnast
Roxanne Potvin (born 1982) Canadian bilingual singer, guitarist and songwriter
Roxanne Pulitzer (born 1951), American novelist and actress
Roxanne Qualls (born 1953), American mayor of Cincinnati, Ohio
Roxanne Quimby (born 1950), American artist and businesswoman
Roxanne Roberts (born 1954), American style writer for the Washington Post
Roxanne Seeman (born 1954), American songwriter and lyricist
Roxanne Shanté (born 1969), American hip hop musician
Roxanne Starr, American graphic designer and comic book letterer
Roxanne Swentzell (born 1962), American ceramist
Roxanne Tong, Hong Kong beauty pageant contestant
Roxanne Wilson (born 1979), American businesswoman
Roxanne Ashley Yu (born 1997), Filipino swimmer