Rossetti is an Italian surname. Notable people with the surname include:
Biagio Rossetti (c. 1447–1516), architect and urbanist from Ferrara, the first to use modern methods
Carlo Rossetti (1614 - 1681), Italian Catholic cardinal
Cezaro Rossetti (1901-1950), Scottish Esperanto writer
C. A. Rosetti (1816–1885) Romanian literary, academia, and political leader, of noble Byzantine descent
Christina Georgina Rossetti (1830–1894), English poet
Dante Gabriel Rossetti (1828–1882), English poet, illustrator, painter and translator, founder member of the Pre-Raphaelite Brotherhood
Francesco Rossetti (1833–1885), Italian physicist
Gabriele Rossetti (1783–1854), poet, scholar and Italian émigré to England, father of Dante Gabriel, Christina Georgina, William Michael, and Maria Francesca
Gino Rossetti (1904–1992), Italian footballer
Maria Francesca Rossetti (1827–1876), English author
Mario J. Rossetti (1935-2014), American jurist
Stefano Rossetti (or Rossetto) (fl. 1560–1580), Italian composer to the Medici
Stephen Joseph Rossetti (born 1951), Roman Catholic priest, author, lecturer and psychologist
William Michael Rossetti (1829–1919), English writer and critic, founder member of the Pre-Raphaelite Brotherhood
Giuseppina Rossetti mother of Lorenzo Respighi an Italian mathematician and natural philosopher