Roque is a surname. Notable persons with that surname include:
Ademir Roque Kaefer (born 1960), Brazilian football player
Alphonse Roque-Ferrier (1844-1907), French philologist.
Ana Roque de Duprey (1853–1933), Puerto Rican educator and suffragist
Bruno Roque de Sousa (born 1989), Brazilian football player
Carlos Roque (1936–2006), Portuguese comics artist
Christine Roque (born 1965) French singer
Felipe Pérez Roque (born 1965), Cuban politician
Frank Roque (born 1959), American convicted murderer
Hélio Roque (born 1985), Portuguese football player
Horácio Roque (1944–2010), Portuguese financier and businessman
Humbert Roque Versace (1937–1965), American soldier
Humberto Roque Villanueva (born 1943), Mexican politician
Jacinto Roque de Sena Pereira (1784–1850), Portuguese sailor
Jacqueline Roque (1927–1986), French model
Joao Roque (born 1971), Angolan mixed martial arts fighter
Juan Roque (born 1974), American football player
Maicon Pereira Roque (born 1988), Brazilian football player
Mariano Roque Alonzo (died 1853), Paraguayan politician
Marta Beatriz Roque (born 1945), Cuban political dissident
Miki Roque (born 1988), Spanish football player
Nuno Roque (born 1987), Portuguese actor and singer
Rafael Roque (born 1972), Dominican baseball player
Randolph Roque Calvo, American Roman Catholic bishop
