Rook is a surname. Notable people with the surname include:
Aaron P. Rook (1892-1969), writer, musician, novelist and travel writer
Alan Rook, editor of the 1936 issue of New Oxford Poetry, one of the Cairo poets
Jean Rook (1931–1991), British newspaper columnist
Jerry Rook (born 1943), American former professional basketball player
Susan Rook, journalist and photographer