Roe is a surname. Notable people with the surname include:
Alban Roe (1583-1642), English Benedictine martyr
Alliott Verdon Roe (1877–1958), British aircraft manufacturer
Anne Roe (1904-1991), American clinical psychologist and researcher
Arthur Roe (1878-1942), American politician
Brian Roe (1939–2014), English cricketer
Charles Roe (1715–1781), English industrialist
David Roe (born 1965), English snooker player
Edward Payson Roe (1838–1888), American novelist
Erica Roe Twickenham streaker (born 1957)
Eugene Roe (1921–1998), medic of the 506th Parachute Infantry Regiment
Francis Asbury Roe (1823–1901), United States Navy admiral
James M. Roe (born 1943), American astronomer
Jane Roe (pseudonym), a legal pseudonym similar to Jane Doe
Jerry D. Roe (born 1936), American academic
John Septimus Roe (1797–1878), first Surveyor-General of Western Australia
Kris Roe, member of The Ataris
Marie Roe, married name of Marie Stopes
Marion Roe (born 1936), United Kingdom politician
Michael Roe (born 1954), American record producer
Philip L. Roe, professor of aerospace engineering
Reginald Heber Roe (1850–1926), 2nd headmaster of Brisbane Grammar School, 1st vice chancellor of University of Queensland
Richard Roe (pseudonym), a legal pseudonym similar to John Doe
Robert A. Roe (born 1924), member of U.S. House of Representatives
Sir Thomas Roe (or Row, c. 1581–1644), English diplomat of the Elizabethan and Jacobean periods
Tim Roe (born 1989), Australian cyclist
Tommy Roe (born 1942), American pop music singer and songwriter
William Gordon Roe, Bishop of Huntingdon