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Rocaglamide

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Rocaglamide is a natural product which belongs to a class of molecules called flavaglines. This compound was isolated in 1982 by King and colleagues based on its antileukemic activity. Like other flavaglines, rocaglamide displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities.

Rocaglamide was first synthesized by Barry Trost in 1990. Although other syntheses have been described since, Trost’s remains the only one to afford rocaglamide in an enantio-specific manner.

References

Rocaglamide Wikipedia


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