Samiksha Jaiswal (Editor)

Rimcazole

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ATC code
  
none

PubChem CID
  
53389

UNII
  
C3N1PS8CX1

CAS Number
  
75859-04-0

ChemSpider
  
48221

ChEMBL
  
CHEMBL275707

Rimcazole

Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor. Sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. Trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. Rimcazole has been shown to reduce the effects of cocaine, and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models.

References

Rimcazole Wikipedia