Ribonucleoside triphosphate reductase

Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase. This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H₂O ⇌ ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.