Suvarna Garge (Editor)

Repulsive guidance molecule

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Symbol
  
RGMA

Entrez
  
56963

OMIM
  
607362

Alt. symbols
  
RGM

HUGO
  
30308

RefSeq
  
NM_020211

Repulsive Guidance Molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.

References

Repulsive guidance molecule Wikipedia


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