Reina is a surname. Notable people with the surname include:
Antonio Manuel Reina (born 1981), Spanish middle-distance runnerArmando Betancourt Reina, Cuban journalist and authorCarlos Roberto Reina (1926–2003), former President of HondurasCalcedonio Reina (1842–1911), Italian painter and poetCasiodoro de Reina (1520–1594), Spanish Lutheran theologianDaniela Reina (born 1981), Italian sprinterDennis Reina (born 1950), American psychologist and authorDomenico Reina (1796-1843), Swiss bel canto tenorGaetano Reina (1889–1930), Boss of the Lucchese crime familyGiuseppe Reina (born 1972), German footballerHarold Reina (born 1990), Colombian footballerJavier Reina (born 1989), Colombian footballerJuanita Reina (1925-1999), Spanish actress and singerLoris Reina (born 1980), French footballerMiguel Reina (born 1946), Spanish footballer, and father of Pepe ReinaMiguel A. Reina (born 1980), Mexican filmmakerPepe Reina (born 1982), Spanish footballerRicky Reina (born 1971), English footballerRoger Reina, American wrestling coachSergio Reina (born 1985), Colombian footballerSisto Reina (died 1664), Italian composer