Reina is a surname. Notable people with the surname include:
Antonio Manuel Reina (born 1981), Spanish middle-distance runner
Armando Betancourt Reina, Cuban journalist and author
Carlos Roberto Reina (1926–2003), former President of Honduras
Calcedonio Reina (1842–1911), Italian painter and poet
Casiodoro de Reina (1520–1594), Spanish Lutheran theologian
Daniela Reina (born 1981), Italian sprinter
Dennis Reina (born 1950), American psychologist and author
Domenico Reina (1796-1843), Swiss bel canto tenor
Gaetano Reina (1889–1930), Boss of the Lucchese crime family
Giuseppe Reina (born 1972), German footballer
Harold Reina (born 1990), Colombian footballer
Javier Reina (born 1989), Colombian footballer
Juanita Reina (1925-1999), Spanish actress and singer
Loris Reina (born 1980), French footballer
Miguel Reina (born 1946), Spanish footballer, and father of Pepe Reina
Miguel A. Reina (born 1980), Mexican filmmaker
Pepe Reina (born 1982), Spanish footballer
Ricky Reina (born 1971), English footballer
Roger Reina, American wrestling coach
Sergio Reina (born 1985), Colombian footballer
Sisto Reina (died 1664), Italian composer
