ATC code none PubChem CID 73110 ChEBI CHEBI:135511 | CAS Number 93908-02-2 ChemSpider 65891 | |
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Synonyms 7,10-dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione | ||
Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from Streptomyces sp. It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases. It shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). It is an antineoplastic antibiotic and an intercalating agent.
Becatecarin (BMS-181176) is a synthetic analog of rebeccamycin.
Rebeccamycin and becatecarin have been texted in phase II clinical trials for the treatment of lung cancer, liver cancer, breast cancer, lymphoma, retinoblastoma, kidney cancer, and ovarian cancer.
References
Rebeccamycin Wikipedia(Text) CC BY-SA