EC number 2.1.1.48 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9076-81-7 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a rRNA (adenine-N6-)-methyltransferase (EC 2.1.1.48) is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + rRNAThus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N6-methyladenine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase. Other names in common use include ribosomal ribonucleate adenine 6-methyltransferase, gene ksgA methyltransferase, ribonucleic acid-adenine (N6) methylase, ErmC 23S rRNA methyltransferase, and S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1QAM, 1QAN, 1QAO, 1QAQ, 1YUB, and 2ERC.