Species Human Entrez 80196 | Human Mouse Ensembl ENSG00000170633 | |
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Aliases RNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34 External IDs MGI: 2153340 HomoloGene: 11839 GeneCards: RNF34 | ||
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
References
RNF34 Wikipedia(Text) CC BY-SA