Species Human Entrez 6035 | Human Mouse Ensembl ENSG00000129538 | |
 | ||
Aliases RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic External IDs MGI: 97919 HomoloGene: 7919 GeneCards: RNASE1 | ||
Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.
Function
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
References
RNASE1 Wikipedia(Text) CC BY-SA