EC number 6.5.1.4 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 85638-41-1 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a RNA-3'-phosphate cyclase (EC 6.5.1.4) is an enzyme that catalyzes the chemical reaction
ATP + RNA 3'-terminal-phosphate
Thus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate.
This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming). This enzyme is also called RNA cyclase.
Structural studies
As of 2010, three structures have been solved for this class of enzymes, with PDB accession codes 1QMH and 1QMI, (un-adenylated) and 3KGD (adenylated).
References
RNA-3'-phosphate cyclase Wikipedia(Text) CC BY-SA